Rhein-Plast is a company in the Industrial Packaging Liner industry

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API handling

Containment solutions for API handling

Safe, dust-free handling of highly active pharmaceutical ingredients (APIs/HPAPIs) to ensure personnel protection and product purity.

Pharmaceuticals

Containment

HPAPI

OEB

Overview

Highly active ingredients require closed systems

Professional API handling is crucial for safety in pharmaceutical production. In particular, when dealing with highly active pharmaceutical ingredients (HPAPIs), operators must be protected from exposure and products from cross-contamination. Open processes pose a considerable risk in this context. To meet the strict OEB requirements (Occupational Exposure Band) and ensure the highest level of safety, closed containment systems are essential. These systems enable dust-free handling of APIs and minimise the risks to people and materials, which is fundamental to GMP-compliant working.

The risks of API handling

Dust generation and particle exposure

Unprotected processes expose operators to harmful dusts and jeopardise compliance with occupational exposure limits (OEL).

Cross-contamination between batches

Product residues from earlier batches can contaminate subsequent batches and affect their quality and safety.

Compliance with OEB classifications

Achieving and maintaining containment levels up to OEB 6 containment requires specialised and validated systems that comply with regulatory requirements such as REACH.

OUR SOLUTIONS

Rhein-Plast containment packaging materials for APIs

Rhein-Plast offers flexible and efficient containment systems for API handling. Our solutions, such as continuous liners and transfer bags, are made from high-quality, GMP-compliant polyethylene films. They enable closed, dust-free transfer of powders and liquids and can be seamlessly integrated into existing filling and production processes. This approach ensures not only the protection of personnel, but also the integrity of the product. Our systems are designed for demanding HPAPI containment and support you in meeting the highest safety standards.

Continuous Liner

Continuous film packs

Transfer bag

Continuous Liner

Continuous film packs

Transfer bag

Continuous Liner

Continuous film packs

Transfer bag

Continuous Liner

Continuous film packs

Transfer bag

advantages

Ensuring product purity

Maximum personal protection

Effective protection of employees against highly active substances.

Ensuring product purity

Prevention of contamination through a closed process chain.

Protection against cross-contamination

Single-use systems prevent the transfer of active substances between different batches.

Seamless integration

Integration into isolators and cleanroom processes of ISO classes 5, 7 and 8 for maximum product purity and the highest process reliability.

Products

Suitable products for your API handling

Request a containment solution for your API process now

Speak with our containment experts about your individual requirements.